Found! Gene that make alcoholics relapse!

London, Nov 16 (IANS) Scientists have identified a particular variant of a gene that plays spoiltsport in people’s recovery from alcoholism, besides subjecting them to 10 times higher risk of premature death.

‘Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population,’ says study co-author Claudia Fahlke, from Sweden’s Sahlgrenska Academy.

Sahlgrenska researchers have found that a variant of the dopamine D2 receptor gene is overrepresented in people with severe alcohol dependency, the journal Alcohol and Alcoholism reports.

The gene variant is linked to a number of different negative consequences that can be of vital bearing on the person affected, according to a Sahlegrenska statement.

This gene variant is tied with higher incidence of relapses among these individuals even if they have undergone treatment for their alcohol dependency, the researchers conclude.

Read more http://in.news.yahoo.com/found-gene-alcoholics-relapse-082256348.html

Found! Gene that make alcoholics relapse!

London, Nov 16 (IANS) Scientists have identified a particular variant of a gene that plays spoiltsport in people’s recovery from alcoholism, besides subjecting them to 10 times higher risk of premature death.

‘Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population,’ says study co-author Claudia Fahlke, from Sweden’s Sahlgrenska Academy.

Sahlgrenska researchers have found that a variant of the dopamine D2 receptor gene is overrepresented in people with severe alcohol dependency, the journal Alcohol and Alcoholism reports.

The gene variant is linked to a number of different negative consequences that can be of vital bearing on the person affected, according to a Sahlegrenska statement.

This gene variant is tied with higher incidence of relapses among these individuals even if they have undergone treatment for their alcohol dependency, the researchers conclude.

Read more http://in.news.yahoo.com/found-gene-alcoholics-relapse-082256348.html

Gene impedes recovery from alcoholism

16.11.2011 – (idw) University of Gothenburg

People who are alcohol-dependent and who also carry a particular variant of a gene run an increased risk of premature death. This is a recent finding from the interdisciplinary research at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden. Researchers in the longitudinal project Göteborg Alcohol Research Project (GARP) have been investigating the dopamine D2 receptor gene and found that a variant of this gene is overrepresented in people with severe alcohol dependency, and that it is linked to a number of different negative consequences that can be of vital significance to the person affected.

Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population, says Claudia Fahlke, a representative from the research team.

In a study published recently in the journal Alcohol and Alcoholism (issue 46), the research team shows that this gene variant also appears to be associated with a higher tendency among these individuals to suffer a relapse, even if they have undergone treatment for their alcohol dependency. This may provide one explanation as to the higher mortality rate in people suffering from alcohol dependency, who are carriers of this gene variant.

This knowledge emphasises the importance of developing methods for early identifying individuals who are also carriers of this gene variant, since the consequences can be so serious, says Jan Balldin at the Sahlgrenska Academy, University of Gothenburg.

Bibliographic data
Journal: Oxford Journals Alcohol and Alcoholism (September-October 2011) 46(5): 509-513 first published online May 25, 2011
Title: Do Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse? A Pilot Study
doi: 10.1093/alcalc/agr045

For more information, please contact: Kristina Berglund
Telephone: +46 (0)31 7861878, or +46 (0)72 2886488
E-mail: Kristina.Berglund@psy.gu.se jQuery(document).ready(function($) { $(“fb_share”).attr(“share_url”) = encodeURIComponent(window.location); });
Weitere Informationen: http://alcalc.oxfordjournals.org/content/46/5/509.full

Read more http://www.uni-protokolle.de/nachrichten/id/227542/

Gene impedes recovery from alcoholism

16.11.2011 – (idw) University of Gothenburg

People who are alcohol-dependent and who also carry a particular variant of a gene run an increased risk of premature death. This is a recent finding from the interdisciplinary research at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden. Researchers in the longitudinal project Göteborg Alcohol Research Project (GARP) have been investigating the dopamine D2 receptor gene and found that a variant of this gene is overrepresented in people with severe alcohol dependency, and that it is linked to a number of different negative consequences that can be of vital significance to the person affected.

Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population, says Claudia Fahlke, a representative from the research team.

In a study published recently in the journal Alcohol and Alcoholism (issue 46), the research team shows that this gene variant also appears to be associated with a higher tendency among these individuals to suffer a relapse, even if they have undergone treatment for their alcohol dependency. This may provide one explanation as to the higher mortality rate in people suffering from alcohol dependency, who are carriers of this gene variant.

This knowledge emphasises the importance of developing methods for early identifying individuals who are also carriers of this gene variant, since the consequences can be so serious, says Jan Balldin at the Sahlgrenska Academy, University of Gothenburg.

Bibliographic data
Journal: Oxford Journals Alcohol and Alcoholism (September-October 2011) 46(5): 509-513 first published online May 25, 2011
Title: Do Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse? A Pilot Study
doi: 10.1093/alcalc/agr045

For more information, please contact: Kristina Berglund
Telephone: +46 (0)31 7861878, or +46 (0)72 2886488
E-mail: Kristina.Berglund@psy.gu.se jQuery(document).ready(function($) { $(“fb_share”).attr(“share_url”) = encodeURIComponent(window.location); });
Weitere Informationen: http://alcalc.oxfordjournals.org/content/46/5/509.full

Read more http://www.uni-protokolle.de/nachrichten/id/227542/

CRANBURY: Cranbury takes ‘proactive’ mode against bullying


CRANBURY: Cranbury takes ‘proactive’ mode against bullying

DATE POSTED: Thursday, October 20, 2011 5:06 PM EDT


David Kilby, Managing Editor

   CRANBURY — The Cranbury Board of Education had its anti-bullying training session this Tuesday, but many of their questions regarding the Anti-Bullying Bill of Rights remained unanswered.

   School officials unanimously agreed the best approach is a proactive one that teaches students to create a healthy learning environment of good communication and respect for one another.

   The Anti-Bullying Bill of Rights is new legislation that requires school districts to appoint anti-bullying teams and conduct investigations for every report of bullying at their schools.

   Dr. Susan Genco, Cranbury chief school administrator, and Sally Bittner, anti-bullying specialist for the Cranbury School District, helped clarify some of the guidelines the Department of Education has promulgated.

   The DOE has been working on an Anti-Bullying Bill of Rights since about 2002, but about a year ago, the cause gained momentum after the suicide of Rutgers student Tyler Clementi.

   Mr. Clementi jumped off the George Washington Bridge in September 2010 after his roommate filmed a video of him having a sexual encounter, then posted it on the Internet.

   During their training session, members of the board asked Dr. Genco and Ms. Bittner how the board ought to implement the legislation.

   ”In larger districts, it’s a coordinated effort,” Dr. Genco said, adding not only do larger districts deal with bullying on a small scale, but they also have the resources to implement districtwide programs.

   But in the Cranbury School District, she said school officials and teachers can focus on what’s happening at Cranbury School since it is the only school in the district.

   The New Jersey Commission on Bullying in Schools defines harassment, intimidation or bullying as an act that substantially disrupts or interferes with the orderly operation of the school or the rights of other students. To be considered HIB, the act must create a hostile educational environment for the student by interfering with a student’s education or by severely or pervasively causing physical or emotional harm to the student.

   Dr. Genco said the key phrase in that definition is “substantially disrupts or interferes with the order of the school or the rights of the student.”

   She added, “Out-of-school conduct must disrupt the order of the school (in order for there to be an investigation). If bullying occurs off school grounds, then comes into the school, then an investigation can be launched.”

   She said there still are many gray areas in the legislation, and it’s something districts are exploring together.

   Lynne Schwarz, president of the board, asked if, for example, a student is affected by e-mails received outside of school, so much so it causes her to sit alone during lunch, does that qualify as disrupting or interfering with the order of the school?

   Ms. Bittner responded that there is a form that needs to be filled out before an investigation begins, and through the form, the anti-bullying team will determine whether an investigation is necessary.

   ”Things can be happening outside of school, but not brought in the school day,” Dr. Genco said. “It’s a very gray area, and cases should be dealt with individually.”

   Ms. Bittner pointed out there is a difference between bullying and conflicts, and the school is looking at ways to resolve conflicts in the school without the need of a bullying investigation.

   Dr. Genco has to make a report to the DOE of all bullying investigations twice a year. The DOE then will use the reports to grade each school and implement new policies and programs.

   The anti-bullying team must meet at least twice a year.

   ”We meet almost daily so we have far exceeded this requirement,” Dr. Genco said.

   She added, “Proactive measures is what they’re looking for. We’re working with students, teaching them to be advocates for themselves and work with one another so that we’re preventing further bullying acts from being committed.”

   A bullying investigation involves 12 steps, and the board must hold a meeting within 10 days of a reported act of bullying. If there is no board meeting scheduled, the board has to call an emergency meeting to complete the investigation, Dr. Genco said.

   The state has provided no funding for these investigations, but did provide resources for implementing the legislation Monday.

   If an individual promptly reports a bullying incident, and the incident is not remedied, the legislation protects the individual from liability.

   The district’s anti-bullying team is continuing to learn more about the legislation and plans to send Ms. Bittner to outside professional development classes to move along the process.

   In addition, in October, Cranbury School has implemented a program to promote respect among students with the theme, “Choose Respect. Give it, Get it.”

   Austin Schraudenbach, vice president of the board, asked what the board is allowed to do and what it is required to do while emphasizing the legislation was not very clear in that regard.

   ”The remedial measures are an including-but-not-limited-to list,” Dr. Genco said.

   ”It’s an infinity of what to do,” Mr. Schraudenbach said.

   ”Due to the policy’s vagueness, all we have to say is what the school administration has done is appropriate or we think (the investigation) needs to be revisited,” said Kevin Fox, board member and head of policy.

   Dr. Genco said she has spoken to different attorneys about what the district needs to do exactly to implement this policy, and they’ve all given her different answers.

   ”We would definitely seek legal advice. We wouldn’t be hasty with our decision because this is uncharted territory,” she said regarding the steps the district would take in an investigation.

   Essentially, the overarching approach the district is taking is a proactive approach, and in doing that, it’s important for the district to be have “one community and one voice,” Dr. Genco said.

   Now that the board has been trained in the legislation, the teachers and students will be trained.

   ”We want to make sure our language is not only consistent but clear,” Dr. Genco said.

   She said creating a positive culture and climate is the most important force against bullying in Cranbury School.

   ”I really think you’ve done a great job understanding what the school already does,” said Evelyn Spann, board member. “I like how you say we’re going to be proactive and not reactive.”

   At the end of her presentation, Dr. Genco gave a district report on violence and vandalism. It said there were four acts of violence and one act of vandalism in the 2009-10 school year, and six acts of violence and no reports for vandalism at the school in the 2010-11 school year.


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Read more http://www.centraljersey.com/articles/2011/11/15/cranbury_press/news/doc4ea085e8d27b9595526861.txt

Gene impedes recovery from alcoholism, Swedish research finds

ScienceDaily (Nov. 15, 2011) — People who are alcohol-dependent and who also carry a particular variant of a gene run an increased risk of premature death. This is a recent finding from the interdisciplinary research at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden.

Researchers in the longitudinal project Göteborg Alcohol Research Project (GARP) have been investigating the dopamine D2 receptor gene and found that a variant of this gene is overrepresented in people with severe alcohol dependency, and that it is linked to a number of different negative consequences that can be of vital significance to the person affected.

“Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population,” says Claudia Fahlke, a representative from the research team.

In a study published recently in the journal Alcohol and Alcoholism (issue 46), the research team shows that this gene variant also appears to be associated with a higher tendency among these individuals to suffer a relapse, even if they have undergone treatment for their alcohol dependency. This may provide one explanation as to the higher mortality rate in people suffering from alcohol dependency, who are carriers of this gene variant.

“This knowledge emphasises the importance of developing methods for early identifying individuals who are also carriers of this gene variant, since the consequences can be so serious,” says Jan Balldin at the Sahlgrenska Academy, University of Gothenburg.

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Story Source:

The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. Dahlgren, H.-L. Wargelius, K. J. Berglund, C. Fahlke, K. Blennow, H. Zetterberg, L. Oreland, U. Berggren, J. Balldin. Do Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse? A Pilot Study. Alcohol and Alcoholism, 2011; 46 (5): 509 DOI: 10.1093/alcalc/agr045

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Read more http://www.sciencedaily.com/releases/2011/11/111115175356.htm

The serotonin system in women’s brains is damaged more readily by alcohol than that in men’s brains

ScienceDaily (Nov. 15, 2011) — After only four years of problem drinking, a significant decrease in the function of the serotonin system in women’s brains can be seen. This is the system that regulates such functions as impulse control and mood. It takes 12 years before a corresponding decrease is seen in men. This is the conclusion of multidisciplinary research carried out at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden.

The research group in the multidisciplinary project Gothenburg Alcohol Research Project (GARP) has studied for the first time three of the major neurotransmitter substances in the brain in a single individual. They have studied a group of women and a group of men with alcohol dependence. The results will be published in January 2012 in the journal Alcoholism: Clinical & Experimental Research.

“We have used what is known as neuroendocrine techniques to show that it is principally the serotonergic system in the brain that is seriously impaired by alcohol. This is the system that regulates impulse control and mood, among other functions,” says Kristina Berglund, scientist at the Department of Psychology and representative for the research group.

Both men and women suffer adverse effects, but the effects arise much more rapidly in women. The results show that the function of women’s serotonin system has fallen by 50% after as little as four years with problematic alcohol consumption, while it takes 12 years before the function of men’s systems is halved.

“It is important to note that the damage is just as serious in men and women, but the time courses are different. We still don’t know whether the serotonin system can repair itself, but there are research results showing that other damage to the brain can heal after a certain period without alcohol,” says Ulf Berggren of the Sahlgrenska Academy, University of Gothenburg.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Read more http://www.sciencedaily.com/releases/2011/11/111115175354.htm

Gene impedes recovery from alcoholism, Swedish research finds

ScienceDaily (Nov. 15, 2011) — People who are alcohol-dependent and who also carry a particular variant of a gene run an increased risk of premature death. This is a recent finding from the interdisciplinary research at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden.

Researchers in the longitudinal project Göteborg Alcohol Research Project (GARP) have been investigating the dopamine D2 receptor gene and found that a variant of this gene is overrepresented in people with severe alcohol dependency, and that it is linked to a number of different negative consequences that can be of vital significance to the person affected.

“Our research shows that alcohol-dependent individuals, who are also carriers of this gene variant, run 10 times the risk of dying prematurely, compared with the average population,” says Claudia Fahlke, a representative from the research team.

In a study published recently in the journal Alcohol and Alcoholism (issue 46), the research team shows that this gene variant also appears to be associated with a higher tendency among these individuals to suffer a relapse, even if they have undergone treatment for their alcohol dependency. This may provide one explanation as to the higher mortality rate in people suffering from alcohol dependency, who are carriers of this gene variant.

“This knowledge emphasises the importance of developing methods for early identifying individuals who are also carriers of this gene variant, since the consequences can be so serious,” says Jan Balldin at the Sahlgrenska Academy, University of Gothenburg.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. A. Dahlgren, H.-L. Wargelius, K. J. Berglund, C. Fahlke, K. Blennow, H. Zetterberg, L. Oreland, U. Berggren, J. Balldin. Do Alcohol-dependent Individuals with DRD2 A1 Allele Have an Increased Risk of Relapse? A Pilot Study. Alcohol and Alcoholism, 2011; 46 (5): 509 DOI: 10.1093/alcalc/agr045

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Read more http://www.sciencedaily.com/releases/2011/11/111115175356.htm

The serotonin system in women’s brains is damaged more readily by alcohol than that in men’s brains

ScienceDaily (Nov. 15, 2011) — After only four years of problem drinking, a significant decrease in the function of the serotonin system in women’s brains can be seen. This is the system that regulates such functions as impulse control and mood. It takes 12 years before a corresponding decrease is seen in men. This is the conclusion of multidisciplinary research carried out at the Department of Psychology and the Sahlgrenska Academy at the University of Gothenburg, Sweden.

The research group in the multidisciplinary project Gothenburg Alcohol Research Project (GARP) has studied for the first time three of the major neurotransmitter substances in the brain in a single individual. They have studied a group of women and a group of men with alcohol dependence. The results will be published in January 2012 in the journal Alcoholism: Clinical & Experimental Research.

“We have used what is known as neuroendocrine techniques to show that it is principally the serotonergic system in the brain that is seriously impaired by alcohol. This is the system that regulates impulse control and mood, among other functions,” says Kristina Berglund, scientist at the Department of Psychology and representative for the research group.

Both men and women suffer adverse effects, but the effects arise much more rapidly in women. The results show that the function of women’s serotonin system has fallen by 50% after as little as four years with problematic alcohol consumption, while it takes 12 years before the function of men’s systems is halved.

“It is important to note that the damage is just as serious in men and women, but the time courses are different. We still don’t know whether the serotonin system can repair itself, but there are research results showing that other damage to the brain can heal after a certain period without alcohol,” says Ulf Berggren of the Sahlgrenska Academy, University of Gothenburg.

Recommend this story on Facebook, Twitter,
and Google +1:

Other bookmarking and sharing tools:


Story Source:

The above story is reprinted from materials provided by University of Gothenburg, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Read more http://www.sciencedaily.com/releases/2011/11/111115175354.htm

Study: Alcoholism strongly linked to specific gene mutations

LOS ANGELES — Alcoholism and other substance-use disorders appear strongly linked to a particular gene mutation, researchers reported Tuesday.

Substance-use disorders are thought to arise from a combination of environmental or lifestyle factors and genetic characteristics. Identifying certain genes that are known to predispose people to the disease could be helpful in preventing drug addiction. Researchers have been working to identify some of the prominent gene mutations that could serve as markers.

The study focused on a gene called cannabinoid receptor 1 — or CRN 1. Researchers in Spain examined three variants of the gene that had previously been linked to alcoholism. The genes were identified from blood samples of 298 males with alcoholism and 155 people without addiction. In two of those variants the researchers found a combination of alterations in the normal gene sequence that appear to be inherited together. Those two mutations appear more frequently in people with alcoholism.

“Certain patients consuming a large amount of alcohol will be more likely to develop alcohol dependence according to the possession of specific CNR1 polymorphisms,” the lead author of the study, Rogelio Gonazalez-Sarmiento, of the University of Salamanca, Spain, said in a news release.

The study was published online in the journal Alcoholism: Clinical & Experimental Research.

Another study in that journal, published Tuesday, estimates that alcohol consumption causes about 4 percent of deaths worldwide and about 5 percent of worldwide disease. Excessive alcohol consumption is linked to an increased risk of infections, diabetes, immune-system disorders, cardiovascular and respiratory disorders, digestive ailments, violence and accidents. It also raises the risk of cancer of the pharynx, oral cavity, liver, larynx, esophagus, rectum, pancreas and, for females, breast cancer.

“These results send a clear message about drinking,” said a co-author of the study, Emanuele Scafato of the Instituto Superiore di Sanita in Italy. “Less is better.”

Read more http://www.heraldnet.com/article/20111115/NEWS02/711159863/1042/LIVING02